Pharmacology & ToxicologybioRxiv
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys
DOI 10.1021/acs.jmedchem.3c00750
Author
V. Du Pont
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2020-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- MicrobiologybioRxiv
Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants
J. Pitts, J. Li, J. Perry…·J. P. Bilello
This study assesses the antiviral activity of remdesivir and GS-441524 against multiple SARS-CoV-2 variants, finding they remain effective against Delta, Omicron, and other variants.
DOI 10.1128/aac.00222-22 - MicrobiologybioRxiv
In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance.
L. Checkmahomed, V. Du Pont, N. C. Riola…·G. Boivin
This study shows that remdesivir resistance in SARS-CoV-2 develops slowly, with a single mutation conferring limited resistance.
DOI 10.1128/aac.00198-22 - MicrobiologybioRxivPreprint
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.
A. Schafer, D. R. Martinez, J. J. Won…·T. P. Sheahan
This paper evaluates the therapeutic efficacy of GS-621763, an oral prodrug of remdesivir, against SARS-CoV-2 in mice, showing reduced viral load and improved lung function.
DOI 10.1101/2021.09.13.460111 - MicrobiologybioRxiv
Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.
A. J. Pruijssers, A. S. George, A. Schäfer…·T. P. Sheahan
This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.