G. Lin

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Geometry theory of distribution shapes for autoregulatory gene circuits

This study mathematically characterizes the phase diagram of protein distribution shapes in autoregulatory gene circuits, identifying three steady-state shapes and their parameter regions.

A specific innate immune response silences the virulence of Pseudomonas aeruginosa in a latent infection model in the Drosophila melanogaster host

This study shows that a latent Pseudomonas aeruginosa infection in Drosophila melanogaster is silenced by an innate immune response, specifically melanization, and provides protection against secondary infections.

Proteomic analysis revealed the function of PoElp3 in development, pathogenicity, and autophagy through the tRNA-mediated translation efficiency in the rice blast fungus

Covalent macrocyclic proteasome inhibitors mitigate resistance in Plasmodium falciparum

This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.

Modelling complex growth profiles of Bacteroides fragilis and Escherichia coli on various carbohydrates in an anaerobic environment

This study develops a bacterial growth model that incorporates growth, death, lag, and tail phases and applies it to Bacteroides fragilis and Escherichia coli on 13 carbohydrates.

Tuning social interactions' strength drives collective response to light intensity in schooling fish

This study shows that varying light intensity affects social interactions and collective behavior in schooling fish by altering their responses to obstacles and group motion patterns.

Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

Context-dependent functions of mitochondria protein quality control in lung

This study shows that mitochondrial protein quality control via LONP1 is context-dependent in lung epithelial cells, affecting proliferation, differentiation, and migration through the integrated stress response.

Structure of the human UBR5 E3 ubiquitin ligase

This paper determines the dimer and tetramer structures of human UBR5, revealing its oligomerization mechanism and functional implications for cancer.

Arabidopsis MLO4 Functions as a Ca2+ Channel Essential for Mechanosensing in Root Tips

This study identifies MLO4 as a Ca2+ channel essential for mechanosensing in Arabidopsis root tips, linking touch stimulation to Ca2+ elevation.

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

Framework estimation of stochastic gene activation using transcription average level

This paper estimates gene activation frameworks and system parameters using average transcription level data, revealing distinct regulation scenarios in mouse fibroblast genes.

Artemisinin-based hybrids produce intracellular proteasome inhibitors that overcome resistance in Plasmodium falciparum

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

All-optical mechanobiology interrogation of YAP in human cancer and normal cells using a novel multi-functional system

This paper introduces an integrated system for automated multi-functional imaging and analysis to study YAP mechanosensitivity in human cells.

Automatic Multi-functional Integration Program (AMFIP) towards All-optical Mechanobiology Interrogation

AMFIP enables automatic multi-functional live-cell imaging by integrating hardware and software without extra costs or hardware, demonstrating its utility in mechanobiology studies.

Bacterium-Enabled Transient Gene Activation by Artificial Transcription Factor for Resolving Gene Regulation in Maize

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19

This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.

Niche Partitioning Between Coastal and Offshore Shelf Waters Results in Differential Expression of Alkane and PAH Catabolic Pathways

The paper compares microbial functional responses to oil and dispersants in coastal and offshore marine waters, finding differential expression of alkane and PAH catabolic pathways.

Resistance to tembotrione, a 4-hydroxyphenylpyruvate dioxygenase-inhibitor, in Sorghum bicolor

This study identifies tembotrione-resistant sorghum genotypes, characterizes their resistance mechanism, and maps quantitative trait loci (QTLs) associated with metabolic resistance to this herbicide.

PHF3 regulates neuronal gene expression through the new Pol II CTD reader domain SPOC

This study identifies PHF3 as a CTD-binding factor that regulates neuronal gene expression by inhibiting Pol II elongation and mRNA stability.

Molecular mimicry in deoxy-nucleotide catalysis: the structure of Escherichia coli dGTPase reveals the molecular basis of dGTP selectivity

This paper determines the structure of Escherichia coli dGTPase and elucidates the molecular basis of its dGTP selectivity through comparative analysis with SAMHD1.

The transcriptome-wide landscape and modalities of EJC binding in adult Drosophila

The paper identifies EJC binding modalities in Drosophila by developing a method to isolate RNA-bound EJC complexes, revealing canonical binding sites and their association with developmental transcripts.