Author

V. Kumarasamy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Witkiewicz· 2 shared E. Knudsen· 2 shared J. Wang· 2 shared A. Dynka· 1 shared A. Ruiz· 1 shared C. Frangou· 1 shared E. V. Abel· 1 shared H. Rosenheck· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

A. Witkiewicz

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2 papers

Recent·Most cited

Pharmacologically targeting KRASG12D in PDAC models:tumor cell intrinsic and extrinsic impact

V. Kumarasamy, C. Frangou, J. Wang, Y. Wan, A. Dynka, H. Rosenheck, P. Dey, E. V. Abel, E. Knudsen, A. Witkiewicz

This study evaluates KRASG12D inhibition in PDAC models, showing variable efficacy in 2D cultures but enhanced response in 3D cultures and xenografts, with immunological modulation contributing to tumor regression.

bioRxiv · Mar 18, 2023Cancer Biology

Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

E. Knudsen, V. Kumarasamy, S. Chung, P. Vail, S. Tzetzo, A. Ruiz, M. Seshadri, S. Abrams, J. Wang, A. Witkiewicz

This study shows that combining MEK and CDK4/6 inhibitors with immune checkpoint inhibitors improves pancreatic cancer treatment by enhancing T-cell infiltration and altering myeloid populations in preclinical models.

bioRxiv · Dec 5, 2019Cancer Biology