Y. Wan

Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes

This study shows that protein interactions, calcium, phosphorylation, and cholesterol regulate CFTR cluster formation on membranes through multivalent interactions and phase separation.

Ancient cyanobacterial proto-circadian clock adapted to short day-night cycles ~ 0.95 billion years ago

The paper reconstructs an ancient cyanobacterial circadian clock from ~0.95 billion years ago and shows it adapts to 18-h day-night cycles but lacks endogenous oscillation.

Comparison of therapeutic effects between pulsed field ablation and cryoballoon ablation in the treatment of atrial fibrillation: a systematic review and me-ta-analysis

This study compares pulsed field ablation (PFA) and cryoballoon ablation (CBA) for atrial fibrillation treatment, finding PFA reduces surgical time and complications but not arrhythmia recurrence.

Rapid in situ mutation detection in extracellular vesicle-DNA

This paper introduces a rapid, PCR- and sequencing-free DNA mutation detection method using CRISPR-Cas12a and extracellular vesicles for cancer diagnosis and treatment monitoring.

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

This study shows vilazodone improves thrombocytopenia by activating SRC/MAPK signaling through 5-HT1A receptor in megakaryocyte differentiation.

Cortical spheroids show strain-dependent cell viability loss and neurite disruption following sustained compression injury

The paper presents an in vitro model of sustained compressive neural injury using cortical spheroids and shows increased DNA damage and microtubule degradation under higher compressive strain.

IS1-related large-scale deletion of chromosomal regions harbouring oxygen-insensitive nitroreductase gene nfsB causes nitrofurantoin heteroresistance in Escherichia coli

The paper identifies IS1-mediated chromosomal deletions in nfsB as a novel mechanism of nitrofurantoin heteroresistance in E. coli.

GATA3 ZnF2-defective mutant condensation underlies type I IFN-activating in breast cancer

This study shows that ZnF2-defective GATA3 mutations impair LLPS and DNA binding, reducing breast cancer progression and enhancing type I IFN signaling.

Pharmacologically targeting KRASG12D in PDAC models:tumor cell intrinsic and extrinsic impact

This study evaluates KRASG12D inhibition in PDAC models, showing variable efficacy in 2D cultures but enhanced response in 3D cultures and xenografts, with immunological modulation contributing to tumor regression.

Single cell Transcriptome and T cell Repertoire Mapping of the Mechanistic Signatures and T cell Trajectories Contributing to Vascular and Dermal Manifestations of Behcet Disease

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

Oxidative phosphorylation pathway disruption is an alternative pathological mechanism leading to Diamond-Blackfan anemia

This study identifies oxidative phosphorylation pathway disruption as an alternative mechanism causing Diamond-Blackfan anemia and shows coenzyme Q10 can rescue erythroid defects.

Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal degeneration

This study shows IDH3B is essential for spermiogenesis but not retinal health, as Idh3b-knockout mice are infertile but have normal vision.

Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation

The paper develops a cell-adaptable hydrogel with stem cells to improve spinal cord injury repair by reducing neuroinflammation and enhancing axonal growth in rats.

Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

This study evaluates a multivalent Ad-vectored vaccine delivered via respiratory mucosal route, showing robust protection against SARS-CoV-2 and variants in mice.

Diverse Genetic Determinants of Nitrofurantoin Resistance in UK Escherichia coli

This study identifies genetic factors causing nitrofurantoin resistance in UK E. coli, finding mutations and insertion sequences in nfsA and nfsB as major contributors.

Wzc and WcaJ mutations in hypervirulent Klebsiella pneumoniae lead to phage resistance at the cost of reduced virulence

This study identifies mutations in wzc and wcaJ genes in hypervirulent Klebsiella pneumoniae that confer phage resistance but reduce virulence.

The PD-L1 and TLR7 dual-targeting nanobody-drug conjugate exerts potent antitumor efficacy by orchestrating innate and adaptive immune responses

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

Subcellular dynamics studies reveal how tissue-specific distribution patterns of iron are established in developing wheat grains

The paper tracks iron translocation in wheat grains using isotope labeling and imaging, revealing symplastic transport and new iron storage structures.

SiCEP3, a C-terminally encoded peptides from Setaria italica, promotes ABA import and signaling pathway

This study identifies SiCEP3, a C-terminally encoded peptide from Setaria italica, which promotes ABA import and signaling by inhibiting receptor kinase activity under abiotic stress.

The Development of a Novel Nanobody Therapeutic for SARS-CoV-2

This paper develops a potent, low-cost nanobody therapeutic, Nanosota-1C-Fc, that effectively blocks SARS-CoV-2 infection in vitro and in vivo with high affinity and stability.

A potent neutralizing nanobody against SARS-CoV-2 with inhaled delivery potential

The paper identifies a potent neutralizing nanobody against SARS-CoV-2 with high activity and stability for inhaled delivery.

Direct RNA sequencing reveals structural differences between transcript isoforms

This study introduces PORE-cupine, a method combining structure probing and nanopore sequencing to detect RNA secondary structures, revealing isoform-specific structural differences and their impact on translation efficiency.

Post-transcriptional splicing can occur in a slow-moving zone around the gene

The paper uses imaging techniques to show that splicing occurs in a slow-moving zone near the transcription site, suggesting a model where splicing is post-transcriptional but occurs close to transcription.

The dominance hierarchy of the female Yunnan snub-nosed monkeys (Rhinopithecus bieti)

The study examines dominance hierarchies among female Yunnan snub-nosed monkeys using aggressive-submissive behaviors and grooming reciprocity, finding loose hierarchies and higher grooming income for dominant individuals.

Evidence of the Recombinant Origin and Ongoing Mutations in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

This study identifies SARS-CoV-2 as a recombinant virus of bat and pangolin coronaviruses and reports ongoing mutations in its genome.

A novel vaccine targeting the viral protease cleavage sites protects Mauritian cynomolgus macaques against vaginal SIVmac251 infection

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

The Manganese Salt (MnJ) Functions as A Potent Universal Adjuvant

This study identifies MnJ, a colloidal manganese salt, as a potent universal adjuvant that induces both humoral and cellular immune responses, including CTL activation and mucosal immunity.

Lung tumour cell-derived exosomes promote the expansion of MDSC through miR-21a/PDCD4/IL-6/STAT3 pathway

This study shows lung cancer exosomes promote MDSC expansion via miR-21a/PDCD4/IL-6/STAT3 pathway, enhancing tumor growth.

Quantitative measurements of chromatin modification dynamics during zygotic genome activation

The paper quantifies chromatin modification dynamics during zygotic genome activation in zebrafish embryos using fluorescent antibody imaging.

Tomato spotted wilt virus manipulates the reproduction of its insect vector, western flower thrips (Frankliniella occidentalis), to facilitate transmission

This study shows that Tomato spotted wilt virus extends the developmental time and increases progeny production in western flower thrips, with a male-biased sex ratio, likely enhancing virus transmission.