M. Seshadri

TNF signaling is required for castration-induced vascular damage preceding prostate cancer regression

This study shows TNF signaling is required for castration-induced vascular damage in prostate cancer, which contributes to tumor regression.

Partial loss of succinate dehydrogenase reduces high red cell distribution width and promotes healthy survival in chronically hypoxic mice

Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

This study shows that combining MEK and CDK4/6 inhibitors with immune checkpoint inhibitors improves pancreatic cancer treatment by enhancing T-cell infiltration and altering myeloid populations in preclinical models.