Author

V. L. Katis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

O. Gileadi· 2 shared A. D. Axtman· 1 shared A. I. Levey· 1 shared A. Michaud· 1 shared D. Wang· 1 shared E. C. Kennedy· 1 shared E. J. Murphy· 1 shared E. L. Zoeller· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersPharmacology & Toxicology

O. Gileadi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants

J. L. Capener, J. D. Vasta, V. L. Katis, A. Michaud, M. T. Beck, S. C. D. Daglish, S. Cohen-Kedar, E. Shaham Barda, S. Howell, I. Dotan, M. B. Robers, A. D. Axtman, F. M. Bashore

The paper develops a NanoBRET assay to study SYK gain-of-function variants in live cells and demonstrates inhibitor efficacy against these variants.

bioRxiv · Jun 12, 2024Cell Biology

Development of a Time-Resolved Fluorescence Resonance Energy Transfer ultra-high throughput screening assay for targeting SYK and FCER1G interaction

Y. Du, D. Wang, V. L. Katis, E. L. Zoeller, M. Qui, A. I. Levey, O. Gileadi, the Emory-SAGE-SGC TREAT-AD Center, H. Fu

This paper develops a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for screening small molecule inhibitors targeting the SYK and FCER1G interaction, identifying hematoxylin as a hit.

bioRxiv · Jun 11, 2024Pharmacology & Toxicology

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2

W. J. Bradshaw, E. C. Kennedy, T. Moreira, L. A. Smith, R. Chalk, V. L. Katis, J. L. Benesch, P. E. Brennan, E. J. Murphy, O. Gileadi

The paper determines structures of SHIP1 and SHIP2 phosphatase and C2 domains, showing the C2 domain modulates phosphatase activity more in SHIP2 than SHIP1, providing insights for drug development.

bioRxiv · Jul 31, 2023Biochemistry