Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
A. Roeselova, S. L. Maslen, S. Shivakumaraswamy, G. A. Pellowe, S. Howell, D. Joshi, J. Redmond, S. Kjaer, M. Skehel, D. Balchin
The paper investigates how chaperones coordinate during cotranslational protein folding in bacteria, showing they create a protected space for maturation without destabilizing intermediates.
Molecular Cell · Jul 1, 2024Peer-reviewedBiochemistry
J. L. Capener, J. D. Vasta, V. L. Katis, A. Michaud, M. T. Beck, S. C. D. Daglish, S. Cohen-Kedar, E. Shaham Barda, S. Howell, I. Dotan, M. B. Robers, A. D. Axtman, F. M. Bashore
The paper develops a NanoBRET assay to study SYK gain-of-function variants in live cells and demonstrates inhibitor efficacy against these variants.
bioRxiv · Jun 12, 2024Cell Biology
F. M. Bashore, S. M. Min, X. Chen, S. Howell, C. H. Rinderle, G. Morel, J. A. Silvaroli, C. I. Wells, B. A. Bunnell, D. Drewry, N. S. Pabla, S. K. Ultanir, A. N. Bullock, A. D. Axtman
The paper identifies and characterizes a chemical probe for CDKL2, demonstrating its selectivity and biological impact in neurons and cancer cells.
bioRxiv · May 12, 2024Cell Biology
E. Lockyer, F. Torelli, S. Butterworth, O.-R. Song, S. Howell, A. Weston, P. East, M. Treeck
The paper identifies a heterotrimeric complex of Toxoplasma proteins that enhances parasite survival in IFNγ-activated human cells.
bioRxiv · Dec 8, 2022 · PreprintMicrobiology
T. E. Wales, A. Pajak, A. Roeselova, S. Shivakumaraswamy, S. Howell, F.-U. Hartl, J. R. Engen, D. Balchin
This study uses HDX-MS to map the cotranslational folding pathway of E. coli dihydrofolate reductase, revealing structured intermediates and chaperone interactions on the ribosome.
bioRxiv · Sep 23, 2022Biochemistry
D. H. Drewry, F. M. Potjewyd, J. L. Smith, S. Howell, A. D. Axtman
This paper identifies a chemical probe for PI5P4Kγ, demonstrating its selectivity and cellular activity, and shows it activates mTORC1 signaling in breast cancer cells.
bioRxiv · Sep 8, 2022Cell Biology
F. M. Potjewyd, A. B. Marquez, A. Chaikuad, S. Howell, A. S. Dunn, A. A. Beltran, J. L. Smith, D. H. Drewry, A. S. Beltran, A. D. Axtman
The paper identifies chemical tools that inhibit TTBK1 and TTBK2, showing that TTBK2 inhibition reduces ciliogenesis in iPSCs.
bioRxiv · May 6, 2022 · PreprintCell Biology
A. Antonopoulos, S. Doyle, D. J. Bartley, A. A. Morrison, R. Kaplan, S. Howell, C. Neveu, V. Busin, E. Devaney, R. Laing
This study develops an allele-specific PCR assay to detect the S168T SNP in acr-8, a marker of levamisole resistance in Haemonchus contortus, and validates it in laboratory and field samples.
bioRxiv · Apr 8, 2022Microbiology
L. E. L. Romano, W. Y. Aw, K. M. Hixson, T. V. Novoselova, T. M. Havener, S. Howell, C. L. Hall, L. Xing, J. Beri, S. Nethisinghe, L. Perna, A. Hatimy, G. Chioccioli Altadonna, L. M. Graves, L. E. Herring, , J. M. Wolter
This study identifies sacsin's role in integrin trafficking and synaptic organization, showing its deficiency causes cellular phenotypes in ARSACS.
bioRxiv · Aug 20, 2021 · PreprintCell Biology
P. D. Jimenez-Castro, S. Howell, J. J. Schaefer, R. W. Avramenko, J. Gilleard, R. Kaplan
The paper investigates anthelmintic resistance in Ancylostoma caninum by analyzing resistance ratios and genetic polymorphisms in resistant isolates.
bioRxiv · Jun 21, 2019Zoology
M. S. Ismail, S. R. Martin, N. J. Ball, I. A. Taylor, S. Howell, D. G. Wilkinson, S. J. Smerdon
This paper identifies a mechanism where Btbd6 recruits Plzf to Cul3 E3 ligase complexes through BTB domain heterodimerization, enabling Plzf ubiquitination.
bioRxiv · Mar 12, 2019 · PreprintBiochemistry