V. Mendes

Thermopriming-associated proteome and sugar content responses in Pinus radiata embryogenic tissue

This study examines proteome and sugar content changes in Pinus radiata embryogenic tissue after heat treatment to understand thermopriming mechanisms.

A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.

This study uses a fragment-based approach to assess the ligandability of four enzymes in the L-arginine biosynthesis pathway of M. tuberculosis, identifying potential drug targets.

Inhibiting Mycobacterium tuberculosis CoaBC by targeting a new allosteric site.

The paper identifies potent inhibitors of Mycobacterium tuberculosis CoaB by targeting a novel allosteric site, based on structural and biochemical analyses of CoaBC.

Mycobacterial OtsA structures unveil substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate

The paper reports the first mycobacterial OtsA structures from M. thermoresistibile, revealing substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate.

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.