Author

A. J. Garcia-Saez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. Cosentino· 2 shared U. Ros· 2 shared A. Girault· 1 shared A. Jenner· 1 shared A. Le Pape· 1 shared A. Lefevre· 1 shared A. P. Gilmore· 1 shared A. Robert· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

K. Cosentino

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1

T. Froehlich, A. Jenner, C. Cavarischia-Rega, F. O. Fagbadebo, Y. Lurz, D. I. Frecot, P. D. Kaiser, S. Nueske, A. Scholz, E. Schaeffer, A. J. Garcia-Saez, B. Macek, U. Rothbauer

This study develops nanobodies to monitor Drp1, a mitochondrial fission factor, using proteomics, microscopy, and live-cell imaging techniques to study its dynamics in disease models.

bioRxiv · Dec 18, 2023 · PreprintCell Biology

Ferroptosis propagates to neighboring cells via cell-cell contacts

B. F. Roeck, M. R. H. Vorndran, A. J. Garcia-Saez

This study uses an optogenetic system to induce ferroptosis and shows that cell death spreads to neighboring cells through cell-cell contacts in a distance- and confluence-dependent manner.

bioRxiv · Mar 24, 2023 · PreprintCell Biology

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

M. Gueguinou, S. Ibrahim, J. Bourgeais, A. Robert, T. Pathak, X. Zhang, D. Crottes, J. Dupuy, D. Ternant, V. Monbet, R. Guibon, H. Flores-Romero, A. Lefevre, S. Lerondel, A. Le Pape, , T. Lecomte

This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.

bioRxiv · Jan 18, 2022Cancer Biology

Systematic assessment of the accuracy of subunit counting in biomolecular complexes using automated single molecule brightness analysis

J. S. H. Danial, Y. Quintana, U. Ros, R. Shalaby, E. G. Margheritis, S. Chumpen, C. Ungermann, A. J. Garcia-Saez, K. Cosentino

This paper develops an automated computational pipeline to assess subunit counting accuracy in biomolecular complexes using single molecule brightness analysis across simulated and experimental data.

bioRxiv · Nov 22, 2021Biophysics

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

L. Pedrera, R. A. Espiritu, U. Ros, A. Schmitt, S. Hailfinger, A. J. Garcia-Saez

This study shows that ferroptosis involves Ca2+ fluxes and ESCRT-III activation, which delay cell death and modulate inflammation.

bioRxiv · Dec 8, 2019Cell Biology

Bax mitochondrial residency is more critical than Bax oligomerization for apoptosis

T. Kuwana, L. King, K. Cosentino, J. Suess, A. J. Garcia-Saez, A. P. Gilmore, D. D. Newmeyer

This study shows that Bax mitochondrial residency, not oligomerization, is critical for apoptosis, using mutants in cell-free and cellular systems.

bioRxiv · Apr 29, 2019 · PreprintCell Biology