MicrobiologybioRxivPreprint
Modulation of macrophage defense responses by Mycobacterial persistence protein MprA (Rv0981) in human THP-1 cells: effect of single amino acid variation on host-pathogen interactions
K. Bhattacharyya, U. Bandopadhyay, A. Singh…·V. Brahmachari
This study shows that the MprA variant G70S in M. tuberculosis reduces phago-lysosome fusion and increases immune suppressive cytokines in THP-1 macrophages, supporting pathogen persistence.
DOI 10.1101/2020.04.27.063602