M. Bose

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype

The paper identifies an X4-tropic HIV-1 transmitted/founder virus in a person with wild-type CCR5, showing faster CD4 depletion and resistance to certain bNAbs.

An architectural role of oskar mRNA in granule assembly

This study investigates how oskar mRNA's kissing-loop interaction contributes to RNP granule assembly in Drosophila oocytes, showing its role in condensate formation and posterior RNA localization.

Overexpression of MUC1 influences the anti-proliferative effect of STAT3-inhibitor Napabucasin in epithelial cancers.

This study shows that overexpressed MUC1 enhances the anti-proliferative effect of the STAT3 inhibitor Napabucasin in epithelial cancers.

Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts.

The paper analyzes an Indian colorectal cancer fecal microbiome cohort, showing global CRC-associated patterns but highlighting regional variations and the importance of local studies.

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

The paper tracks the coreceptor switch of HIV-1 in early infection, finding that a single mutation can drive X4 variants and co-evolution of antigenicity and tropism.

In vitro Isolation of Treponema pallidum subsp. pallidum from Fresh and Frozen Needle Aspirates of Primary Experimental Syphilis Lesions

This paper describes an in vitro method to isolate Treponema pallidum subsp. pallidum from clinical samples without using rabbits.

Ca2+-dependent liquid-liquid phase separation underlies intracellular Ca2+ stores.

The paper identifies Ca2+-dependent liquid-liquid phase separation in CASQ1, a Ca2+ binding protein in skeletal muscle, explaining Ca2+ buffering and storage mechanisms.

Liquid-to-solid phase transition of oskar RNP granules is essential for their function in the Drosophila germline

This study shows that oskar RNP granules in Drosophila oocytes undergo a liquid-to-solid phase transition, which is essential for their function in germline formation.

Repression of MUC1 promotes expansion and suppressive function of myeloid-derived suppressor cells in pancreatic ductal adenocarcinoma and breast cancer murine models.

This study shows that MUC1 repression in MDSCs enhances their proliferation and suppressive function in pancreatic and breast cancer models, leading to increased tumor growth and immune suppression.

Tumor -Associated MUC1 Regulates TGF-β Signaling and Function in Pancreatic Ductal Adenocarcinoma

This study shows that high tMUC1 expression in PDA correlates with altered TGF-β signaling, promoting tumor growth and resistance to TGF-β therapy.

Modulation of macrophage defense responses by Mycobacterial persistence protein MprA (Rv0981) in human THP-1 cells: effect of single amino acid variation on host-pathogen interactions

This study shows that the MprA variant G70S in M. tuberculosis reduces phago-lysosome fusion and increases immune suppressive cytokines in THP-1 macrophages, supporting pathogen persistence.

Correlation of drug resistance with Single Nucleotide Variations through genome analysis and experimental validation in a multi-drug resistant clinical isolate of M.tuberculosis.

The paper identifies SNVs in a multi-drug resistant M. tuberculosis isolate and shows their functional impact on drug resistance through genome analysis and experimental validation.

Overcoming Immunological Resistance Enhances the Efficacy of a Novel anti-tMUC1 CAR T Cell Treatment Against Pancreatic Ductal Adenocarcinoma

This study develops a novel tMUC1-targeting CAR T cell therapy for pancreatic ductal adenocarcinoma and shows that combining it with inhibitors of IDO1, COX1/2, and Gal-9 enhances its efficacy against resistant tumors.