Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis
O. Iriondo, D. Mecenas, Y. Li, C. R. Chin, A. Thomas, Y. Amzaleg, A. Moriarty, V. Ortiz, M. MacKay, A. Dickerson, G. Lee, S. Harotoonian, B. A. Benayoun, A. D. Smith, C. Mason, , M. Yu
The paper shows hypoxia induces a long-lasting suppression of type I interferon and antigen presentation in breast cancer cells, enhancing metastasis and being reversible with HDACi and immunotherapy.
bioRxiv · May 12, 2022 · PreprintCancer Biology