C. Lopez

A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone

This study evaluates combinations of PDAC biomarkers across multiple labs, finding improved sensitivity and specificity for early-stage detection compared to CA19-9 alone.

Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp.

This study investigates the molecular mechanisms of cefiderocol resistance and antagonism with avibactam and sulbactam in carbapenem-resistant Acinetobacter strains.

Advancing Cell Therapies: Single-Cell Profiling, Generation, Expansion, and Gene Delivery in Rhesus Macaque Plasma B Cells

This study expands NHP B cells ex vivo, identifies unique plasma cell markers, and establishes AAV transduction conditions for engineered B cell therapies.

Climatic refugia in the coldest neotropical hotspot, the Andean paramo

The paper identifies climatic refugia in the Andean paramo during the Last Glacial Maximum using species distribution models and finds refugia concentrated in specific regions and associated with plant traits.

Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis

This study shows that FGF9 overexpression in airway epithelial cells increases type I interferon response and leads to more severe influenza A virus infection and mortality.

Spatial effects in parasite induced marine diseases of immobile hosts

This study develops a spatially-explicit model to analyze how parasite mobility affects disease transmission in sessile marine hosts, showing that higher mobility leads to more severe epidemics and faster extinction.

Cytidine deaminase protects pancreatic cancer cells from replicative stress and drives resistance to DNA-targeting drugs

This study shows that Cytidine deaminase (CDA) protects pancreatic cancer cells from replication stress and contributes to resistance against DNA-targeting drugs.

Efficient methods for generation and expansion of, and gene delivery to Rhesus Macaque plasma B cells

The paper develops methods to expand and transduce rhesus macaque B cells for potential cell therapy applications.

What makes our lungs look red?

The paper identifies a distinct population of red cells in lung tissues, called Red Soma Cells (RSC), which contribute to lung redness and have unique biological functions.

Species exclusion and coexistence in a noisy voter model with a competition-colonization tradeoff

This study uses a noisy voter model to examine species competition, showing outcomes like exclusion, mono-stable, and bi-stable coexistence depending on immigration and competition-dispersal tradeoffs.

Visualization of the HIV-1 Env Glycan Shield Across Scales

This study uses cryo-EM, computational modeling, and mass-spectrometry to analyze the HIV-1 Env glycan shield's structure and dynamics, revealing how heterogeneity and interactions affect epitope accessibility and trimer stability.

The H-NS regulator plays a role in the stress induced by carbapenemase expression in Acinetobacter baumannii

This study shows H-NS alleviates envelope stress from MBL expression and DNA-damaging agents in A. baumannii, linking it to stress response and carbapenem resistance.

Spatial eco-evolutionary feedbacks mediate coexistence in prey-predator systems

This paper investigates eco-evolutionary feedbacks in prey-predator systems with spatial constraints, showing that predator perceptual range evolution influences species coexistence and extinction probabilities.

IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer

This study shows that adding IL2 to rapamycin increases the persistence of ex-vivo expanded regulatory T cells in non-human primates, doubling their numbers in peripheral blood.

A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes

This study identifies a specific RSV genomic sequence that regulates the generation of copy-back defective viral genomes, showing that cbDVG formation is not random and can be manipulated.