Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice
R. N. Helsley, T. Miyata, A. Kadam, V. Venkateshwari, N. Sangwan, E. C. Huang, R. Banerjee, A. L. Brown, K. K. Fung, W. Massey, C. Neumann, O. Danny, L. J. Osborn, R. C. Schugar, M. R. McMullen, , J. M. Brown
This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.
bioRxiv · Dec 31, 2021Biochemistry