Author

N. Sangwan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:human· 2

Frequent Co-Authors

J. M. Brown· 3 shared S. L. Hazen· 3 shared D. S. Allende· 2 shared J. Claesen· 2 shared L. E. Nagy· 2 shared L. J. Osborn· 2 shared M. Dwidar· 2 shared P. P. Ahern· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiochemistry

J. M. Brown

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

HMGB1 acts as an agent of host defense at the gut mucosal barrier

A.-M. C. Overstreet, B. Anderson, M. Burge, X. Zhu, Y. Tao, C. Cham, B. Michaud, S. Horam, N. Sangwan, M. Dwidar, X. Liu, A. Santos, C. Finney, Z. Dai, V. Leone, J. S. Messer

This study identifies HMGB1 as a host defense molecule in the gut mucosal barrier that targets bacterial adhesins to prevent microbial invasion and adhesion.

bioRxiv · May 30, 2023 · PreprintMicrobiology

Miltefosine attenuates inflammation, reduces atherosclerosis, and alters gut microbiota in hyperlipidemic mice.

C. A. Traughber, A. J. Iacano, M. R. Khan, K. Nepane, E. Opoku, T. Nunn, N. Sangwan, S. L. Hazen, J. Smith, K. Gulshan

bioRxiv · Aug 22, 2022 · PreprintCell Biology

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

R. N. Helsley, T. Miyata, A. Kadam, V. Venkateshwari, N. Sangwan, E. C. Huang, R. Banerjee, A. L. Brown, K. K. Fung, W. Massey, C. Neumann, O. Danny, L. J. Osborn, R. C. Schugar, M. R. McMullen, , J. M. Brown

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

bioRxiv · Dec 31, 2021Biochemistry

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

L. J. Osborn, K. Schultz, W. Massey, B. DeLucia, I. Choucair, V. Varadharajan, K. Fung, A. J. Horak, D. Orabi, I. Nemet, L. E. Nagy, Z. Wang, D. S. Allende, N. Sangwan, A. M. Hajjar, , J. Claesen

bioRxiv · Sep 16, 2021Microbiology

Bacillus anthracis chain length, a virulence determinant, is regulated by a transmembrane Ser/Thr protein kinase PrkC

M. Gupta, Y. Singh, N. Dhasmana, N. Kumar, A. Gangwal, C. c. keshavam, L. K. Singh, N. Sangwan, P. nashier, S. biswas, A. P. Pomerantsev, S. H. Leppla

This study identifies PrkC, a transmembrane Ser/Thr kinase in B. anthracis, as a regulator of bacterial chain length, which impacts virulence and pathophysiological outcomes.

Journal of Bacteriology · May 7, 2021Peer-reviewedMicrobiology

Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy

L. Chambers, E. L. Esakov, C. Braley, L. Trestan, Z. Alali, D. Bayik, J. Lathia, N. Sangwan, P. Bazeley, A. S. Joehlin-Price, M. Dwidar, A. Hajjar, P. P. Ahern, J. Claesen, P. Rose, , O. Reizes

This study shows that antibiotic treatment disrupts the gut microbiome, leading to increased resistance to cisplatin in ovarian cancer models.

bioRxiv · Jun 16, 2020 · PreprintCancer Biology