A Newcastle disease virus-vector expressing a prefusion-stabilized spike protein of SARS-CoV-2 induces protective immune responses against prototype virus and variants of concern in mice and hamsters
W. Sun, Y. Liu, F. Amanat, I. Gonzalez-Dominguez, S. McCroskery, S. Slamanig, L. Coughlan, V. Rosado, N. Lemus, S. Jangra, R. Rathnasinghe, M. Schotsaert, J. Martinez, K. Sano, I. Mena, , P. Palese
This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.
bioRxiv · Jul 6, 2021 · PreprintImmunology