M. Schotsaert

Enhanced mucosal B- and T-cell responses against SARS-CoV-2 after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant.

This study shows that combining intramuscular mRNA priming with intranasal protein boosting using a combination adjuvant enhances mucosal B- and T-cell responses against SARS-CoV-2 compared to other vaccination regimens.

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice.

This study evaluates how lipid nanoparticle (LNP) composition and adjuvant combinations affect immune responses and protection in mice vaccinated against influenza.

A 3D Printed Ventilated Perfused Lung Model Platform to Dissect the Lung's Response to Viral Infection in the Presence of Respiration

This study develops a 3D printed lung model to investigate how ventilation affects viral infection and lung responses in vitro.

Protocol for primary human lung organoid-derived air-liquid interface in vitro model to study response to SARS-CoV-2

This paper presents a protocol for creating human lung organoid-derived air-liquid interface cultures to study SARS-CoV-2 infection and includes quality control and monitoring methods.

SARS-CoV-2 infection triggers pro-atherogenic inflammatory 1 responses in human coronary vessels

This study shows SARS-CoV-2 infects macrophages in coronary atherosclerotic lesions, causing inflammation that may increase cardiovascular risk.

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters

This study evaluates hybrid immunity in mRNA-vaccinated hamsters during breakthrough infections, finding enhanced cross-reactive immune responses despite low neutralizing antibody titers.

Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia

This study examines the spatiotemporal immune response to SARS-CoV-2 in human broncho-alveolar epithelia, finding variant-specific kinetics and spatially organized gene expression patterns.

Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants.

This study develops a measles-based vaccine encoding SARS-CoV-2 spike glycoproteins that enhances neutralizing antibody responses against both omicron and historical variants.

Rescue of alveolar wall liquid secretion blocks fatal lung injury by influenza-staphylococcal coinfection

This study shows that influenza virus inhibits alveolar wall liquid secretion, promoting fatal lung injury from staphylococcal infection, and that restoring this secretion protects against lung damage.

Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice

The paper tests a trivalent NDV-HXP-S vaccine against SARS-CoV-2 variants in mice, showing increased protection and cross-neutralizing antibodies against Omicron.

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters

The paper shows that nitazoxanide inhibits SARS-CoV-2 replication and pathogenesis in human and hamster models, and synergizes with remdesivir against multiple variants.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Development of an HIV reporter virus that identifies latently infected CD4+ T cells

This study develops an HIV reporter virus to identify latently infected CD4+ T cells and finds that over 50% of infected cells harbor silent proviruses.

A Newcastle disease virus-vector expressing a prefusion-stabilized spike protein of SARS-CoV-2 induces protective immune responses against prototype virus and variants of concern in mice and hamsters

This study develops a Newcastle disease virus-based vaccine expressing a prefusion-stabilized SARS-CoV-2 spike protein, showing strong immune responses and cross-neutralization against variants in mice and hamsters.

Prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine.

This study shows that a live attenuated influenza virus vaccine lacking NS1 provides broad protection against respiratory viruses including SARS-CoV-2 by inducing both innate and adaptive immune responses.

A Combination Adjuvant for the Induction of Potent Antiviral Immune Responses for a Recombinant SARS-CoV-2 Protein Vaccine

This study develops a combination adjuvant that enhances antiviral immune responses to a SARS-CoV-2 protein vaccine, showing improved TH1 responses and neutralizing antibodies against variants in mice.

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

This paper demonstrates that a novel TLR7/8 agonist adjuvant enables single-shot protection against SARS-CoV-2 and influenza in mice using recombinant spike protein and inactivated vaccines.

Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model

This study shows that deleting the polybasic cleavage site and introducing proline mutations in the SARS-CoV-2 spike protein enhances vaccine efficacy in a mouse model.

Comparative in vitro transcriptomic analyses of COVID-19 candidate therapy hydroxychloroquine suggest limited immunomodulatory evidence of SARS-CoV-2 host response genes.

This study examines HCQ's transcriptomic effects in vitro and finds limited overlap with SARS-CoV-2 host response genes, suggesting limited immunomodulatory evidence for HCQ in COVID-19.

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection

This study compares two SARS-CoV-2 infection models in mice: K18-hACE2 transgenic and adenovirus-mediated hACE2 delivery, showing differences in viral replication and disease outcomes.