PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension
T. V. Kudryashova, S. V. Zaitsev, L. Jiang, B. J. Buckley, J. P. McGuckin, D. Goncharov, I. Zhyvylo, D. Lin, G. Newcomb, B. Piper, S. Bogamuwa, A. Saiyed, L. Teos, M. Ranson, P. Wolters, , V. Stepanova
This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.
bioRxiv · Sep 21, 2023Cell Biology