Author

G. Newcomb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

B. Piper· 2 shared E. A. Goncharova· 2 shared L. Farkas· 2 shared S. Bogamuwa· 2 shared T. V. Kudryashova· 2 shared A. Green· 1 shared A. L. Mora· 1 shared A. R. Bhagwani· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

B. Piper

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension

T. V. Kudryashova, S. V. Zaitsev, L. Jiang, B. J. Buckley, J. P. McGuckin, D. Goncharov, I. Zhyvylo, D. Lin, G. Newcomb, B. Piper, S. Bogamuwa, A. Saiyed, L. Teos, M. Ranson, P. Wolters, , V. Stepanova

This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.

bioRxiv · Sep 21, 2023Cell Biology

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

B. Piper, S. Bogamuwa, T. Hossain, D. Farkas, L. Rosas, A. Green, G. Newcomb, N. Sun, J. C. Horowitz, A. R. Bhagwani, H. Yang, T. V. Kudryashova, M. Rojas, A. L. Mora, P. Yan, , L. Farkas

This study shows RAB7 deficiency impairs endothelial function and causes pulmonary hypertension in mice, with potential for RAB7 activation as a therapeutic strategy.

bioRxiv · Feb 3, 2023Physiology