M. A. Atkinson

Impaired islet function with normal exocrine enzyme secretion is consistent across the head, body, and tail pancreas regions in type 1 diabetes

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.

Human immune phenotyping reveals accelerated aging in type 1 diabetes

The paper uses flow cytometry to show accelerated immune aging and age-adjusted proinflammatory phenotypes in type 1 diabetes.

Serum from pregnant donors induces human beta cell proliferation and insulin secretion

This study shows that serum from pregnant donors can stimulate human beta cell proliferation and insulin secretion, suggesting potential for beta cell expansion.

Immune, endothelial and neuronal network map in human lymph node and spleen

The paper maps immune, endothelial, and neuronal networks in human spleen and lymph node using multiplex imaging, revealing novel cellular localization patterns.

A Gut Microbial Peptide and Molecular Mimicry in the Pathogenesis of Type 1 Diabetes

This paper identifies a gut microbial peptide that mimics an insulin epitope and contributes to Type 1 Diabetes pathogenesis by triggering immune cross-reactivity and accelerating disease onset in mice.

ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

Pancreatlas: applying an adaptable framework to map the human pancreas in health and disease

Pancreatlas provides a web resource for exploring annotated human pancreas images, integrating multiple imaging technologies into an adaptable framework for data access and analysis.