D. McKenzie

Solution-phase indexing by kinetic confinement enables rapid, simple, and instrument-free single cell transcriptional profiling

This paper introduces an instrument-free method for single-cell transcriptional profiling using kinetic confinement and bifunctional indexing reagents, enabling rapid and scalable analysis.

Fibronectin: a natural barrier against prion infection

This study identifies fibronectin as a natural barrier against prion infection by showing its association with PrPSc and its ability to reduce prion infectivity in vitro and in tissues.

The efficacy of EphA2 tyrosine phosphorylation increases with EphA2 oligomer size

This study investigates the relationship between EphA2 oligomer size and signaling efficacy, finding a correlation between mean oligomer size and tyrosine phosphorylation.

Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

This study develops a human Proximal Tubule Kidney-Chip to assess renal transporter-based drug-drug interactions and demonstrates its ability to predict clinical outcomes and clearance values.

Tissue-intrinsic γδ T cells critically regulate Tissue-Resident Memory CD8 T cells

This study shows that tissue-intrinsic γδ T cells regulate TRM cells via a feedback loop involving IFNγ and PD-L1, affecting TRM function and cancer response.

High-throughput screens of PAM-flexible Cas9 variants for gene knock-out and transcriptional modulation

The paper compares PAM-flexible Cas9 variants (xCas9 and Cas9-NG) and wild-type Cas9 across gene knock-out, activation, and suppression using a high-throughput screen, finding that PAM flexibility reduces targeting efficiency and that Cas9-NG outperforms xCas9.