W. I. Weis

This study investigates how multiple cadherin-catenin complexes interact with F-actin under force and how vinculin enhances this interaction, revealing cooperative mechanisms that strengthen cell-cell junctions.

This study identifies the E-cadherin/{beta}-catenin/E-catenin complex's catch bond mechanism with F-actin, showing the ABD's role in force-dependent binding and its impact on cytoskeletal linkages.

This study identifies distinct autoinhibitory mechanisms in T-catenin and E-catenin regulating vinculin binding, showing that T-catenin's N-terminus maintains M-region autoinhibition.

The paper describes the cryo-EM structure of E-catenin's actin-binding domain and explains how mechanical force affects its binding to F-actin, revealing the mechanism of catch bond behavior.

This study uses lattice micropatterning to improve the positioning of endothelial cells on EM grids, enabling more efficient cryo-electron tomography of cell-cell contacts.

The paper shows that Dvl and Axin oligomerization dynamics regulate Wnt/β-catenin signaling efficiency by controlling β-catenin phosphorylation inhibition.

This paper introduces a technology to study mesoscale organization in epithelial cells under morphological modulation using ECM micropatterning for cryogenic electron microscopy.