N. Volkmann

MEPSi: A tool for simulating tomograms of membrane-embedded proteins

MEPSi simulates tomograms of membrane-embedded proteins to evaluate and optimize cryo-ET data acquisition parameters before experimental imaging.

Novel ACE2 nanoparticles universally block SARS-CoV-2 variants in the human respiratory tract

This study develops hACE2 nanoparticles that block SARS-CoV-2 and its variants by sequestering viruses through aggregation in cell systems and human respiratory tract explants.

ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

Structural basis of αE-catenin-F-actin catch bond behavior

The paper describes the cryo-EM structure of E-catenin's actin-binding domain and explains how mechanical force affects its binding to F-actin, revealing the mechanism of catch bond behavior.

Extracellular matrix micropatterning technology for whole cell cryogenic electron microscopy studies

This paper introduces a technology to study mesoscale organization in epithelial cells under morphological modulation using ECM micropatterning for cryogenic electron microscopy.

Accurate alignment between correlated light, cryo-light, and electron cryo-microscopy data using sample support features

The paper describes a marker-free method to align light and electron cryo-microscopy data using carbon film holes, achieving sub-100 nm alignment accuracy.