A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity.
A. J. McCann, J. Lou, M. Moustaqil, A. Blum, F. Fontaine, H. Liu, W. Luu, P. Koopman, E. Sierecki, Y. Gambin, F. A. Meunier, Z. Liu, E. Hinde, M. Francois
This study investigates how a dominant-negative SOX18 mutant disrupts transcription factor activity by interfering with chromatin-binding dynamics and recruiting the wild-type interactome.
bioRxiv · Nov 11, 2020Cell Biology