J. Lou

Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels

This study investigates how different crosslinker architectures affect the viscoelastic properties of dynamic covalent hydrogels, showing that side-chain and telechelic crosslinkers lead to distinct mechanical behaviors.

The small molecule CBR-5884 inhibits the Candida albicans phosphatidylserine synthase

The paper identifies CBR-5884 as a potent inhibitor of Candida albicans Cho1, showing fungistatic effects and disrupting in vivo Cho1 function.

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

Single cell expression and chromatin access of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential pivotal controller of a ribosome regulon

The paper maps transcriptional and chromatin changes during the Toxoplasma gondii lytic cycle, identifying AP2XII-8 as a key regulator of a ribosome regulon.

Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations

A computational model predicts influenza virus evolution and aids in vaccine strain selection by modeling site-wise mutation dynamics.

Sorcin-STAT3-Serpin E1/CCL5 axis can be the trigger of pancreatic cancer-associated new-onset diabetes

This study identifies a Sorcin-STAT3-Serpin E1/CCL5 signaling axis that drives pancreatic cancer-associated new-onset diabetes by impairing beta-cells and elevating serpin E1 levels in peripheral blood.

Oligomeric state of β-coronavirus non-structural protein 10 stimulators studied by OmniSEC and Small Angle X-ray Scattering

This study characterizes the oligomeric state and structure of nsp10 from SARS, MERS, and SARS-CoV-2 using biochemical and biophysical methods, revealing it is predominantly monomeric and globular.

Immuno-Engineered Mitochondria for Efficient Therapy of Acute Organ Injuries via Modulation of Inflammation and Cell Repair

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

This study analyzes NSP10 variants in SARS-CoV-2 using genomic data and biophysical methods, finding limited functional changes and strong conservation in its interactions with NSP14 and NSP16.

The GxcM-Fbp17/RacC-WASP signaling cascade regulates polarized cortex assembly in migrating cells

This study identifies a signaling cascade involving GxcM, Fbp17, RacC, and WASP that regulates rear cortical actin assembly in migrating Dictyostelium cells.

Two ligand-binding sites on SARS-CoV-2 non-structural protein 1 revealed by fragment-based x-ray screening

This study identifies two ligand-binding sites on SARS-CoV-2 nsp1 using X-ray crystallography and fragment-based screening, offering a foundation for inhibitor development.

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

Structure of SOQ1 lumenal domains identifies potential disulfide exchange for negative regulation of photoprotection, qH

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity.

This study investigates how a dominant-negative SOX18 mutant disrupts transcription factor activity by interfering with chromatin-binding dynamics and recruiting the wild-type interactome.

Is there a need for preoperative α-blocker in patients missed preoperative diagnosis of extra-adrenal retroperitoneal paraganglioma undergoing paraganglioma resection? A retrospective study of 167 cases at a single center

This study evaluates the impact of preoperative α-blocker use on outcomes in extra-adrenal retroperitoneal paraganglioma surgeries, finding no significant differences in postoperative complications.

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

Characterization of the evolutionary dynamics of influenza A H3N2 hemagglutinin

This study introduces a statistical method to analyze mutation dynamics in influenza A H3N2, showing regional mutation contributions to global epidemics and identifying key amino acids for therapeutic targets.

CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

This study shows that CTCF degradation promotes distal VH-to-DJH joining by enabling cohesin-driven RAG-scanning in pro-B cells.

FcγRIIB I232T polymorphic change allosterically suppresses ligand binding

This study shows that the I232T SNP in FcγRIIB causes structural changes that reduce ligand binding, contributing to SLE pathogenesis.

Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.

The paper develops a biophysical method to quantify chromatin compaction dynamics during DNA damage response using FLIM-FRET microscopy and identifies roles of ATM and RNF8 in chromatin reorganization.