W. Xi

A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge

This paper develops a minimal physical model to explain curvotaxis by simulating curved protein complexes at the cell's leading edge and shows it matches experimental observations on curved substrates.

Effect of cell membrane tension on the lifetime and size of mature clathrin-coated pits and their spatial distribution

The paper investigates how membrane tension affects the size, lifetime, and spatial distribution of clathrin-coated pits during maturation.

Structural basis for substrate recruitment by AMBRA1 E3 ligase receptor

This study determines the cryo-EM structure of AMBRA1 bound to DDB1, revealing how AMBRA1 recruits substrates for ubiquitination and its role in autophagy and cell-cycle regulation.

Click by Click Microporous Annealed Particle (MAP) Scaffolds

This paper develops a tunable MAP scaffold using click chemistry to adjust hydrogel rigidity and demonstrates its biocompatibility in an ischemic stroke model.

Stability of Aβ-fibril fragments in the presence of fatty acids

The paper investigates how lauric acid affects the stability of Aβ fibrils, finding it stabilizes toxic Aβ42 fibrils but not Aβ40 fibrils.

Large Fatty Acid-derived Aβ42 oligomers Form Ring-like Assemblies

This study determines the structures of large fatty acid-derived Aβ42 oligomers using molecular dynamics and biophysical methods, revealing ring-like assemblies with distinct sizes and functional properties.

The Effect of Retro-inverse D-Amino Acid Aβ-peptides on Aβ- Fibril Formation

This study investigates how DRI-Aβ peptides affect Aβ fibril formation and suggests they may enhance fibril formation while reducing toxic oligomers, indicating potential for Alzheimer's drug design.

Conversion between parallel and antiparallel β-sheets in wild-type and Iowa mutant fibrils

The paper studies the conversion between parallel and antiparallel β-sheets in wild-type and Iowa mutant Aβ40 fibrils using Hamilton-Replica-Exchange simulations.

Out-of-Register Aβ42 Assemblies as Models for Neurotoxic Oligomers and Fibrils

The paper models neurotoxic Aβ42 oligomers and fibrils using out-of-register C-terminal β-strands and shows their stability through molecular dynamics simulations.