X. Mai

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Structural basis for membrane remodelling by the AP5:SPG11-SPG15 complex

This study determines the structure of the AP5:SPG11-SPG15 complex and shows it binds PI3P, senses membrane curvature, and drives membrane remodeling in vitro.

Lactose and its derivatives are a new class of immune checkpoint inhibitors for cancer therapy

This study identifies lactose and its derivatives as immune checkpoint inhibitors by enhancing CD8+ T-cell function through modulation of galactosylation and Gal-1 interactions.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Structural basis for lipid transfer by the ATG2A-ATG9A complex

This study determines the cryo-EM structures of ATG2A and ATG2A-ATG9A complexes, revealing their roles in lipid transfer during autophagosome formation.

Structural basis for substrate recruitment by AMBRA1 E3 ligase receptor

This study determines the cryo-EM structure of AMBRA1 bound to DDB1, revealing how AMBRA1 recruits substrates for ubiquitination and its role in autophagy and cell-cycle regulation.

Parallel lipid-carried epitope pillars enhance stimulation of chimeric antigen receptor T cells

This study shows that glycosylphosphatidylinositol-anchored MUC1 epitope pillars enhance chimeric antigen receptor T cell stimulation, with tandem repeat sequences showing greater activity.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

An atlas of infiltrated B-lymphocytes in breast cancer revealed by paired single-cell RNA-sequencing and antigen receptor profiling

This study identifies a comprehensive atlas of B-lymphocytes in triple-negative breast cancer using single-cell RNA-sequencing and antigen receptor profiling, revealing their mature characteristics and prognostic significance.