Q. Liao

Cryo-EM structure of monomeric CXCL12-bound CXCR4 in active state

This paper presents a cryo-EM structure of CXCL12-bound CXCR4 in an active state, revealing key interactions that stabilize the ligand-receptor complex.

Intraspecific encounters can induce home-range shifts

This study investigates whether close intraspecific encounters lead to long-term spatial shifts in animal home ranges using movement data from coyotes and grizzly bears.

Cryo-EM structures of the human G-protein coupled receptor 1 (GPR1) - Gi protein complexes bound to the full-length chemerin and to its C-terminal nonapeptide

The paper reports cryo-EM structures of GPR1-Gi complexes bound to full-length chemerin and its C-terminal nonapeptide, revealing a 'two-site' interaction model and structural similarities to CMKLR1-Gi complexes.

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

Using DNA flow-stretching assay as a tool to validate the tagging of DNA-binding proteins for single-molecule experiments

This paper uses a DNA flow-stretching assay to evaluate how a KCK tag affects DNA-binding protein behavior in single-molecule experiments.

Identification of cardiac afterload dynamics from data

The paper develops a method to identify continuous-time transfer functions from sampled data and evaluates its performance on cardiac afterload models.

The jasmine (Jasminum sambac) genome and flower fragrances

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosisby Deep Neural Networks

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

The paper evaluates three 16S rRNA sequencing protocols for vaginal microbiome analysis and identifies biases in species abundance estimation, proposing an optimized protocol to improve accuracy.

Stability of Aβ-fibril fragments in the presence of fatty acids

The paper investigates how lauric acid affects the stability of Aβ fibrils, finding it stabilizes toxic Aβ42 fibrils but not Aβ40 fibrils.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.