Author

W.-C. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Balmain· 1 shared A. R. Krainer· 1 shared C. Ma· 1 shared C.-C. Liao· 1 shared C.-F. Kao· 1 shared C.-P. Sun· 1 shared D. M. McCandlish· 1 shared H.-C. Wu· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Balmain

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4 papers

Recent·Most cited

Self-Healable Spider Dragline Silk Materials

W.-C. Chen, R.-C. Wang, S.-K. Yu, J.-L. Chen, Y.-H. Kao, T.-Y. Wang, P.-Y. Chang, H.-S. Sheu, S. C. C. Chen, W.-R. Liu, T.-I. Yang, H.-C. Wu

This paper develops a self-healing spider silk material with tunable properties and demonstrates its application in wearable electronics.

Advanced Functional Materials · Jun 24, 2023Peer-reviewedBioengineering

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters

R. Kulkarni, W.-C. Chen, Y. Lee, C.-F. Kao, S.-L. Hu, H.-H. Ma, J.-T. Jan, C.-C. Liao, J.-J. Liang, H.-Y. Ko, C.-P. Sun, Y.-S. Lin, Y.-C. Wang, S.-C. Wei, Y.-L. Lin, , W. Chang

This study evaluates two vaccinia virus-based SARS-CoV-2 vaccines in mice and hamsters, showing they induce neutralizing antibodies and protect against infection.

bioRxiv · Aug 3, 2021Immunology

Higher-order epistasis and phenotypic prediction

J. Zhou, M. S. Wong, W.-C. Chen, A. R. Krainer, J. B. Kinney, D. M. McCandlish

This paper introduces a method to model higher-order genetic interactions from partially observed data and applies it to predict phenotypes in antibody-binding domains and splicing efficiency.

bioRxiv · Oct 14, 2020Evolutionary Biology

Regulation of KRAS4A/B splicing in cancer stem cells by the RBM39 splicing complex.

W.-C. Chen, M. D. To, P. M. K. Westcott, R. Delrosario, I.-J. Kim, M. Phillips, Q. Tran, N. Bayani, A. Balmain

This study identifies KRAS4A and KRAS4B splice isoforms with distinct expression patterns in cancer stem cells and shows that targeting KRAS4A splicing is a potential therapeutic strategy in KRAS mutant tumors.

bioRxiv · May 22, 2019 · PreprintCancer Biology