Nrf1 is endowed with a dominant tumor-repressing effect onto the Wnt/β-Catenin-dependent and -independent signaling networks in the human liver cancer
J. Chen, M. Wang, X. Ru, Y. Xiang, Y. Ren, X. Liu, L. Qiu, Y. Zhang
This study shows Nrf1 represses tumor growth by inhibiting Wnt/β-catenin signaling and other pathways through ubiquitination of β-catenin and regulation of key genes.
bioRxiv · Aug 5, 2019Cancer Biology