Author

Y. Aoki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Plant Biology· 2 Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:plant (other)· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

A. Sugiyama· 3 shared J. Yamamoto· 3 shared K. Hamada· 3 shared K. Yazaki· 3 shared M. Bouvet· 3 shared R. M. Hoffman· 3 shared A. J. Nagano· 2 shared H. Matsuda· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersPlant Biology

A. Sugiyama

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide

N. Watanabe, Y. Tone, T. Nagata, S. Masuda, T. Saito, N. Motohashi, K. Takagaki, Y. Aoki, S. Takeda

This study develops NS-089/NCNP-02, a dual-targeting ASO for exon 44 skipping in DMD, showing effective in vitro and in vivo exon skipping and dystrophin expression.

bioRxiv · Feb 23, 2023 · PreprintCell Biology

Apoplast-localized β-Glucosidase Elevates Isoflavone Accumulation in the Soybean Rhizosphere

H. Matsuda, Y. Yamazaki, E. Moriyoshi, M. Nakayasu, S. Yamazaki, Y. Aoki, H. Takase, S. Okazaki, A. J. Nagano, A. Kaga, K. Yazaki, A. Sugiyama

This study shows that apoplast-localized β-glucosidase (ICHG) increases isoflavone accumulation in the soybean rhizosphere but is not required for plant-microbe interactions.

bioRxiv · Dec 13, 2022Plant Biology

A triple-negative matrix-producing breast carcinoma is arrested by tumor-targeting Salmonella typhimurium A1-R in a PDOX model

K. Hamada, J. Yamamoto, C. Hozumi, M. Zhao, T. Murata, N. Sugisawa, Y. Sun, Y. Aoki, H. Nishino, M. Bouvet, T. Tsunoda, R. M. Hoffman

This study evaluates the efficacy of Salmonella typhimurium A1-R in arresting tumor growth in a triple-negative matrix-producing breast carcinoma PDOX model.

bioRxiv · Jan 14, 2021 · PreprintCancer Biology

Histone H3K4me3 and H3K9me3 are super over-methylated in soft tissue sarcoma compared to normal muscle in patient-derived xenograft (PDX) mouse models: an indicator of cancer methionine addiction

Y. Aoki, R. M. Hoffman, K. Nishida, I. Endo, M. Bouvet, Y. Tashiro, S. Inubushi, K. Hamada, Y. Tome, J. Yamamoto

bioRxiv · Jan 1, 2021 · PreprintCancer Biology

The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence

J. Yamamoto, S. Inubushi, Q. Han, Y. Tashiro, N. Sugisawa, K. Hamada, Y. Aoki, K. Miyake, R. Matsuyama, M. Bouvet, S. G. Clarke, I. Endo, R. M. Hoffman

The paper shows that methionine-independent cancer cell revertants have reduced histone H3 lysine trimethylation and lower tumorigenicity and metastatic potential compared to methionine-addicted parental cells.

bioRxiv · Dec 4, 2020 · PreprintCancer Biology

Species-specific assembly of root-associated bacterial microbiota mediated by a combination of plant specialized metabolites

T. Shimasaki, S. Masuda, R. Garrido-Oter, T. Kawasaki, Y. Aoki, A. Shibata, W. Suda, K. Shirasu, K. Yazaki, R. T. Nakano, A. Sugiyama

The paper shows that tobacco-specific PSMs mediate the enrichment of Arthrobacter in the tobacco endosphere through bacterial catabolism.

bioRxiv · Sep 25, 2020 · PreprintMicrobiology

Diurnal metabolic regulation of isoflavones and soyasaponins in soybean roots

H. Matsuda, M. Nakayasu, Y. Aoki, S. Yamazaki, A. J. Nagano, K. Yazaki, A. Sugiyama

This study investigates diurnal regulation of isoflavone and soyasaponin biosynthesis and secretion in soybean roots using transcriptome and metabolite analysis.

bioRxiv · Apr 22, 2020Plant Biology

Cortisol levels adter cold exposure are independent of adrenocorticotropic hormone stimulation

A. M. Shida, T. Ikeda, N. Tani, F. Morioka, Y. Aoki, K. Ikeda, M. Watanabe, T. Ishikawa

This study shows that cortisol levels after cold exposure are not correlated with ACTH levels in human autopsies or in cell culture experiments.

bioRxiv · Jun 13, 2019Biochemistry