N. Watanabe

Mar1, an HMG-box protein, regulates n-alkane adsorption and cell morphology of the dimorphic yeast Yarrowia lipolytica

This study identifies MAR1, an HMG-box protein, as a regulator of n-alkane adsorption and cell morphology in Yarrowia lipolytica through transcriptional control of relevant genes.

Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations

This study uses AI with flow cytometry to identify CML cells with mitochondrial morphological changes, enabling early diagnosis and monitoring of treatment response.

Exon 44 skipping in Duchenne muscular dystrophy: NS-089/NCNP-02, a dual-targeting antisense oligonucleotide

This study develops NS-089/NCNP-02, a dual-targeting ASO for exon 44 skipping in DMD, showing effective in vitro and in vivo exon skipping and dystrophin expression.

Transition to the structurally vulnerable nuclear state is an integral part of mouse embryonic development

The paper shows that mouse embryonic nuclei become structurally and mechanically vulnerable at the 2-cell stage due to lamin B1 loss via autophagy, essential for chromatin organization and zygotic genome activation.

The T. ispahanicum elongated glume locus P2 maps to chromosome 6A and is associated with the ectopic expression of SVP-A1

The study identifies the wheat locus P2, associated with elongated glumes, as mapping to chromosome 6A and linked to ectopic expression of SVP-A1.

Differences in environmental stability among SARS-CoV-2 variants of concern: Omicron has higher stability

This study compares the environmental stability of SARS-CoV-2 variants, finding Omicron has the longest survival time on surfaces and is more resistant to ethanol than the Wuhan strain.

PTEN differentially regulates endocytosis, migration, and proliferation in the enteric protozoan parasite Entamoeba histolytica

This study identifies EhPTEN1 in E. histolytica and shows it differentially regulates endocytosis, migration, and proliferation through PtdIns(3,4,5)P3 signaling.

The kinesin KIF4 mediates HBV/HDV entry through regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.

This paper identifies KIF4 as a critical regulator of NTCP surface localization for HBV/HDV entry and shows RXR agonists can suppress KIF4 to inhibit viral infection.

A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks

The paper proposes a mechanism involving severing near barbed ends and annealing to explain the structure and dynamics of dendritic actin networks in lamellipodia.

Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress

This study compares the composition of normal stress granules and mutant FUS assemblies in stressed cells, identifying molecular differences and their impact on cellular stress responses in ALS-FUS.

Structural characterization of Nonstructural protein 1 from SARS-CoV-2

The paper reports the crystal structure of SARS-CoV-2 Nsp1 and identifies structural features that inform modeling of related viral proteins.

Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease.

This study tests Danshen, Salvianolic acid A, and Salvianolic acid B for their ability to reduce Aβ42 toxicity in PC12 cells and Drosophila Alzheimer's models, showing improved cell viability and behavioral outcomes.

Potential Application of Bacteriophages in Enrichment Culture for Improved Prenatal Streptococcus agalactiae Screening

This study tests using bacteriophages to reduce false negatives in S. agalactiae screening by inhibiting E. faecalis growth in enrichment cultures.