TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin
L. A. B. Swanson, G. D. Katkar, J. Tam, R. Pranadinata, Y. Chareddy, J. E. Coates, M. S. Amandachar, V. Castillo, J. Olson, V. Nizet, I. Kufareva, S. Das, P. Ghosh
This study shows GIV/Girdin dampens TLR4-mediated inflammatory responses in macrophages by inhibiting receptor dimerization and downstream signaling.
bioRxiv · Aug 29, 2020Immunology