PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy
T. Yoshida, K. Z. Latt, A. Z. Rosenberg, B. A. Santo, K. Myakala, Y. Ishimoto, Y. Zhao, S. Shrivastav, B. A. Jones, X. Yang, X. Wang, V. M. Tutino, P. Sarder, M. Levi, K. Okamoto, , J. B. Kopp
This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.
bioRxiv · Oct 3, 2022Pathology