S. Gong

Melatonin serves as a novel treatment in cystic fibrosis and inhibits cystic fibrosis through TGF-β1/Smad and EMT

This study shows melatonin reduces bladder fibrosis by inhibiting the TGF-β1/Smad pathway and epithelial-mesenchymal transition (EMT) in both in vitro and in vivo models.

Prolonging the Delivery of Influenza Virus Vaccine Improves the Quantity and Quality of the Induced Immune Responses in Mice

This study shows that prolonged influenza vaccine delivery in mice enhances both the quantity and quality of immune responses compared to prime-boost immunization.

Krumholzibacteriota and Deltaproteobacteria contain rare genetic potential to liberate carbon from monoaromatic compounds in subsurface coal seams

This study identifies three microbial taxa with genetic potential to degrade monoaromatic compounds in subsurface coal seams, including a novel Krumholzibacteriota species.

Striatonigral distribution of a fluorescent reporter following intracerebral delivery of genome editors

The paper shows that genome editing in the striatum leads to fluorescent reporter expression in the substantia nigra pars reticulata via anterograde axonal transport.

A 3D Clinical Face Phenotype Space of Genetic Syndromes using a Triplet-Based Singular Geometric Autoencoder

This paper develops a triplet-based geometric autoencoder to create a clinical face phenotypic space for syndrome diagnosis, showing it can classify syndromes, generalize to new ones, and preserve genetic disease relationships.

Placental polyamines regulate acetyl-coA and histone acetylation in a sex-dependent manner

The paper shows that placental polyamines affect acetyl-CoA and histone acetylation differently in males and females, linking these changes to pregnancy complications.

PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure

The paper uses PET/CT and fluorescent microscopy to show dIgA increases HIV virion distribution and penetration in colorectal tissue and lymph nodes after exposure.

Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

This study analyzes the roles of two Mg2+ ions in DNA polymerase specificity and catalysis using kinetic analysis and molecular dynamics simulations.

Human Cytomegalovirus Drives WDR5 to the Virion Assembly Compartment to Facilitate Virion Assembly

This paper shows HCMV drives WDR5 to the virion assembly compartment to facilitate virion assembly, expanding its role beyond nuclear egress.

Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primates

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Basis for discrimination by engineered CRISPR/Cas9 enzymes

This study investigates how engineered CRISPR/Cas9 variants improve off-target discrimination by analyzing their kinetic behavior during DNA cleavage.

Cloning, Biochemical Characterization and inhibition of Alanine racemase from Streptococcus iniae

This study characterizes alanine racemase from Streptococcus iniae, identifies inhibitors, and demonstrates their efficacy against both gram-positive and gram-negative bacteria.

PERK inhibition mitigates restenosis and thrombosis - a potential low-thrombogenic anti-restenotic paradigm

This study shows that PERK inhibition reduces restenosis and thrombosis in animal models, suggesting it as a potential therapeutic strategy for drug-eluting stents.

LonP1 Orchestrates UPRmt and UPRER and Mitochondrial Dynamics to Regulate Heart Function

This study shows LonP1 regulates UPRmt and UPRER, and mitochondrial dynamics in cardiomyocytes, impacting heart function and revealing potential therapeutic targets for heart failure.

DNA unwinding is the primary determinant of CRISPR-Cas9 activity

The paper investigates CRISPR-Cas9 activity, finding that DNA unwinding is the primary determinant of its cleavage efficiency.

Senkyunolide A Protects Corticosterone-Induced Cell Apoptosis Via Modulating Protein Phosphatase 2A And α-Synuclein

This study identifies senkyunolide A as a neuroprotective compound that mitigates corticosterone-induced cell apoptosis by modulating PP2A and α-synuclein levels in PC12 cells.