A. Zhou

Cynipid wasps systematically reprogram host metabolism and restructure cell walls in developing galls

This study investigates how Cynipid wasps alter plant metabolism and cell wall structure to form galls, revealing coordinated lignin and xylan deposition in gall vasculature.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Metabolic imprints in the hydrogen isotopes of Archaeoglobus fulgidus tetraether lipids

This study investigates how metabolism and growth conditions affect hydrogen isotope signatures in archaeal lipids, supporting their use as paleohydrological proxies.

Chemoproteomics identifies proteoform-selective caspase-2 inhibitors

The paper identifies proteoform-selective caspase-2 inhibitors using chemoproteomics, revealing a unique non-catalytic cysteine and validating their selectivity and activity.

Mode of carbon and energy metabolism shifts lipid composition in the thermoacidophile Acidianus

This study shows that changes in energy and carbon metabolism in Acidianus sp. DS80 significantly affect the ring index of its membrane lipids, indicating a link between cellular energy state and lipid composition.

Tumors cells with mismatch repair deficiency induce hyperactivation of Pyroptosis resistant to cell membrane damage but are more sensitive to Co-treatment of IFN-γ and TNF-α to PANoptosis

The paper shows that dMMR tumor cells are resistant to membrane damage but sensitive to IFN-γ and TNF-α co-treatment inducing PANoptosis, suggesting a strategy to enhance ICB therapy.

A deep learning approach for improving two-photon vascular imaging speeds

This paper introduces a deep learning method to accelerate two-photon vascular imaging by upscaling low-resolution images and enabling 3D reconstruction, reducing imaging time by up to fourfold.

Identification of a Prunus MAX1 Homolog as a Unique Strigol Synthase from Carlactone Bypassing 5-Deoxystrigol

The paper identifies a Prunus MAX1 homolog as a strigol synthase that bypasses 5-deoxystrigol synthesis, directly converting carlactone to strigol.

The trans-regulatory landscape of gene networks in plants

This study maps the trans-regulatory landscape of gene networks in plants by analyzing effector domains of Arabidopsis transcription factors to understand their functional roles in gene regulation.

Machine learning reveals conserved chromatin patterns determining meiotic recombination sites in plants

The paper uses machine learning to identify key chromatin features that determine meiotic recombination sites in plants, finding that three features can predict crossover sites with 90% accuracy.

Multi-site phosphorylation of yeast Mif2/CENP-C promotes inner kinetochore assembly

The paper identifies multi-site phosphorylation of Mif2/CENP-C as essential for inner kinetochore assembly and accurate chromosome segregation in yeast.

REGEN-COV protects against viral escape in preclinical and human studies

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters

This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.

Prohibitin protects against cigarette smoke extract-induced cell apoptosis in cultured human pulmonary microvascular endothelial cells

This study shows prohibitin protects human pulmonary microvascular endothelial cells from cigarette smoke extract-induced apoptosis by preserving mitochondrial function and reducing oxidative stress.

Multiple environmental parameters impact core lipid cyclization in Sulfolobus acidocaldarius

This study investigates how environmental factors affect lipid cyclization in Sulfolobus acidocaldarius, finding that growth rate correlates with cyclization and suggesting energy availability as a universal driver.

Lower Soil Carbon Loss Due to Persistent Microbial Adaptation to Climate Warming

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

Energy flux controls tetraether lipid cyclization in Sulfolobus acidocaldarius

This paper shows that energy flux affects GDGT cyclization in archaea, linking membrane composition to energy availability across different growth conditions.