Yun Chen

Self-Other Neural Representational Distinction is Associated with Distorted Social Predictions in Social Anxiety

This study investigates how social anxiety affects self-other neural distinctions and social predictions, finding that higher SA correlates with greater self-other representational separation in the pgACC and altered prediction tracking in the precuneus.

Dehydration-Responsive Left-Handed G-Quadruplexes Expandthe Sequence Repertoire

The paper identifies dehydration-responsive left-handed G-quadruplexes (drLHG4s) and expands the sequence space for their formation through mutational analysis and crystal structures.

G4All: a database of experimentally confirmed G-quadruplex-forming sequences

G4All is a curated database of experimentally validated G-quadruplex-forming DNA and RNA sequences with controls, enabling comparative analysis and predictive model development.

NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinoma

This study identifies NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages as drivers of chemoradiotherapy resistance in ESCC through multi-omics analysis of clinical trial data.

Orally surface engineered probiotic system for ulcerative colitis therapy via modulating gut microbiota and immune homeostasis

This paper develops a probiotic system for ulcerative colitis that enhances probiotic survival and colon targeting, modulates gut microbiota and immune responses, and provides a mathematical model for release dynamics.

Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration

The paper identifies SMARCA4 and ERK-ETS signaling as targets for suppressing aging-related dopaminergic degeneration in Parkinson's disease using gene co-expression analysis and Drosophila models.

Sorting Nexin 27 (SNX27): A Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Trafficking

This study identifies SNX27 as a novel regulator of CFTR trafficking, showing it facilitates CFTR recycling and prevents degradation in airway epithelial cells.

Direct Small Molecule Activation of Mitofusins

This study identifies MASM7 as a direct activator of mitofusin 2, promoting mitochondrial fusion through conformational changes.

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters

The paper investigates how promoter spacing influences PROMPT expression, stability, and length, revealing a mechanism for generating alternative TSSs in mammalian transcriptomes.

Mapping and Inheritance analysis of a novel dominant rice male sterility mutant, OsDMS-1

The paper identifies a novel dominant rice male sterility mutant, OsDMS-1, and reports three loci controlling its sterility, conflicting with classical genetic analysis.

The KIAA0319 Gene Polymorphisms are Associated with Developmental Dyslexia in Chinese Uyghur Children

This study identifies KIAA0319 gene polymorphisms associated with developmental dyslexia in Uyghur children using SNP analysis and linkage disequilibrium.