K. Ren

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

This paper introduces a 3D in vitro assay to study immune cell infiltration and cytotoxicity in solid tumors, showing it captures key steps of immune cell interaction with the tumor microenvironment.

Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation

This paper develops a logic-gate activated lysosome targeting DNA nanodevice for controlled protein degradation and modulates T cell-mediated antitumor immunity.

Precision-engineered biomimetics: the human fallopian tube

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

Multiplexed Sequential Imaging in Living Cells with Orthogonal Fluorogenic RNA Aptamer/Dye Pairs

This paper introduces seqFRIES, a method for multiplexed live-cell imaging using orthogonal RNA aptamer/dye pairs, achieving four-color imaging in ~20 minutes.

Targeted RNA Condensation in Living Cells via Genetically Encodable Triplet Repeat Tags

This study introduces a genetically encoded RNA tag to program RNA condensate formation and modulate RNA localization and function in living cells.

Genetically Encoded RNA-based Bioluminescence Resonance Energy Transfer (BRET) Sensors

This paper introduces genetically encoded RNA-based BRET sensors for real-time target detection in living cells, using a luciferase donor and RNA-based acceptor.

A Multivalent Polyomavirus Vaccine Elicits Durable Neutralizing Antibody Responses in Macaques

This study shows a multivalent polyomavirus vaccine induces high, durable neutralizing antibodies in macaques without adverse effects.

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

This study evaluates the effectiveness of S309 and AZD7442 monoclonal antibodies against Omicron variants in mice, showing reduced lung infection despite decreased neutralization in vitro.

Integrative interactome and ubiquitinome analyses reveal multiple regulatory pathways targeted by ICP0 in HSV-1 infected neuronal cells

This study identifies and validates multiple novel targets of HSV-1 ICP0 in neuronal cells using proteomic approaches and functional experiments, revealing potential restrictive activities of SNX9 and OTUD4.

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studies.

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

The paper identifies potent neutralizing antibodies against SARS-CoV-2 that block receptor binding and protect animals, providing insights for vaccine and therapy development.

Loss of FSTL1-expressing adipocyte progenitors drives the age-related involution of brown adipose tissue

This study identifies FSTL1-expressing adipocyte progenitors as drivers of age-related brown adipose tissue involution in rabbits and humans, with loss of FSTL1 causing iBAT atrophy in mice.

Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators

The paper reports cryo-EM structures of RyR2 bound to modulators, revealing how Ca2+ and other molecules regulate channel gating and provide insights into cardiac disorder mechanisms.