B. Ying

An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut

This paper develops an ingestible, battery-free robotic interface for chronic gut electrostimulation, showing it can modulate ghrelin levels and has potential for treating gastrointestinal conditions.

Ipsilateral or contralateral boosting of mice with mRNA vaccines confers equivalent immunity and protection against a SARS-CoV-2 Omicron strain

This study shows that boosting mice with mRNA vaccines in the ipsilateral or contralateral arm leads to equivalent immune responses and protection against SARS-CoV-2 Omicron.

Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2

This study shows that intestinal helminth infection reduces T cell responses to an mRNA SARS-CoV-2 vaccine and weakens protection against Omicron but not the ancestral strain.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

Mucosal Adenoviral-vectored Vaccine Boosting Durably Prevents XBB.1.16 Infection in Nonhuman Primates

This study shows that mucosal adenoviral-vectored vaccines provide durable protection against XBB.1.16 infection in nonhuman primates, outperforming intramuscular boosting in reducing virus replication in both upper and lower airways.

A bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 infection and disease in mice and hamsters

This paper shows a bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 in mice and hamsters through mucosal immunity, despite poor serum neutralizing antibody responses.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domains

The paper develops and evaluates an mRNA vaccine, mRNA-1283, encoding SARS-CoV-2 spike N-terminal and receptor-binding domains, showing improved immunogenicity and protection against multiple variants in mice.

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

This study shows that SARS-CoV-2 boosting induces GC B cell responses and that Omicron-based vaccines can elicit novel epitope-specific antibodies despite antigenic imprinting.

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant

This study evaluates bivalent SARS-CoV-2 mRNA vaccines and finds they induce broader neutralizing antibodies and better protection against BA.5 Omicron compared to monovalent vaccines.

Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

This study shows that boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibodies and protection against B.1.1.529 in mice, with the Omicron-matched booster showing slightly better outcomes.

mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2

This study evaluates the efficacy of mRNA-1273 and Ad26.COV2.S vaccines against the B.1.621 variant in mice and hamsters, showing protection against infection and pathology.

IGF1 Signaling in Temporomandibular Joint Fibrocartilage Stem Cells Regulates Cartilage Growth and Homeostasis in Mice

This study shows that Igf1 deletion in TMJ fibrocartilage stem cells causes cartilage degeneration and worsens osteoarthritis in mice.

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

This study evaluates the protective efficacy of mRNA vaccines against SARS-CoV-2 variants in mice, showing that low-dose vaccines lead to breakthrough infections with Delta variant.

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

This study shows that an intranasal vaccine provides durable protection against SARS-CoV-2 variants in mice, including emerging strains like B.1.351 and B.1.1.28.

Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice

This study evaluates the protective efficacy of modified miniproteins against SARS-CoV-2 in mice, showing reduced viral burden and prevention of lung disease.

Impact of peripheral mutations on the access channels of human cytochrome P450 1A2

The paper investigates how peripheral mutations in CYP1A2 affect substrate channel dynamics using computational models, finding that some mutations disrupt water channels and substrate binding.

Influence of food and Nosema ceranae infection on the gut microbiota of Apis cerana workers

This study examines how food type and Nosema ceranae infection affect the gut microbiota of Apis cerana workers, finding that beebread supports a more stable microbiota and reduces mortality from infection.

Rhamnolipids from Pseudomonas aeruginosa disperse the Biofilms of Sulfate-Reducing Bacteria

This study shows that Pseudomonas aeruginosa supernatants, containing rhamnolipids, effectively disperse biofilms of sulfate-reducing bacteria and other microbes.