Jae‐Yeon Choi

The paper develops a fluorescence-based assay, DAB-APT, to measure aminopropyl transferase activity and inhibition, validated with enzymes from S. cerevisiae and P. falciparum.

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

This study shows that disrupting the PCA pathway in fungi affects vacuolar integrity, drug detoxification, and susceptibility to antifungal drugs, supporting its potential as a therapeutic target.