E. J. Martz

Novel interactions within the silent information regulator heterochromatin complex potentiate inter-subunit communication and gene repression

The paper identifies a novel inter-subunit interaction in the SIR complex that facilitates the switch from histone deacetylation to chromatin compaction, essential for gene repression.

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.