Author
Washington University in St. LouisORCID 0000-0001-5378-0192Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Martina Marras, Joshua D Josef, Thomas Schuster…·Jonathan R. Silva
The paper shows that a common SCN5A variant, S1103Y, alters mexiletine's pharmacological response in induced pluripotent stem cell-derived cardiomyocytes, leading to proarrhythmic effects.
Samuel P. Brown, Ryan J. Lawson, Jonathan D. Moreno, Joseph L. Ransdell
The paper investigates the role of resurgent (INaR) and persistent (INaP) sodium currents in regulating repetitive firing in Purkinje neurons, finding that INaP, not INaR, is critical for firing rate control.
Jingxuan Guo, Huanzhu Jiang, David R. Schuftan…·Nathaniel Huebsch
This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.
Joseph L. Ransdell, Jonathan D. Moreno, Druv Bhagavan…·Jeanne M. Nerbonne
The paper investigates the gating mechanisms of resurgent Na+ currents in mouse cerebellar Purkinje neurons using voltage-clamp recordings and a novel computational model.