James Minton Cook

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.

This study shows that extrasynaptic localization of 5GABAARs is critical for their ability to modulate dopamine system function, as shifting them to synaptic locations abolishes the effect of the 5-PAM GL-II-73.

This study investigates the effects of a 5-GABAAR positive allosteric modulator on ASD-like behaviors in a rat model, finding it reduces social and cognitive deficits without affecting dopamine system activity.

This study evaluates the effects of GABAA receptor modulators in a mouse model of chronic stress, showing antidepressant and pro-cognitive effects with neurotrophic benefits.

This study shows that chronic treatment with a 5-GABA-A receptor PAM increases dendritic length, spine count, and density in mice, suggesting potential for reversing age-related cognitive decline.