Ineke H. N. Luijten

This study evaluates 'kill or cure' strategies for MFN2-related lipodystrophy, finding that ethanol mildly worsens the condition in mice while rapamycin is well-tolerated but lacks efficacy in targeting Mfn2R707W cells.

This study investigates whether increased energy expenditure in Pik3r1-related insulin resistance is due to Ucp1-mediated thermogenesis, finding no evidence for this mechanism.

This study identifies mitochondrial dysfunction and impaired mitophagy in CKD-MBD as contributors to renal osteodystrophy, showing reversible effects with rapamycin treatment.

This study shows that deleting Alms1 in mesenchymal cells in mice causes metabolic issues similar to Alström Syndrome, including insulin resistance and fatty liver.