Colin Farquharson

This study shows that TNAP and PHOSPHO1 are crucial for craniofacial and dental development, with their combined deletion causing severe hypoplasia and mineralisation defects.

The paper identifies a 10 bp deletion in PRICKLE1 causing skeletal dysplasia in Cheviot sheep and develops a DNA test to eliminate the mutation.

This study investigates the synergistic roles of TNAP and PHOSPHO1 in postnatal bone mineralisation using a novel murine knockout model, revealing their critical function in biomineralisation and skeletal development.

This study shows that polyanionic NCPs and their analogues promote artificial mineralization in embryonic mouse bone ECM by facilitating apatite infiltration into collagen fibrils.

This study characterizes the proteome of matrix vesicles from primary osteoblasts, revealing a heterogeneous population with features of both exosomal and ectosomal biogenesis.

This study identifies mitochondrial dysfunction and impaired mitophagy in CKD-MBD as contributors to renal osteodystrophy, showing reversible effects with rapamycin treatment.

This study shows that increased PHOSPHO1 expression in renal osteodystrophy contributes to increased cortical bone mineral density but decreased trabecular bone density.

This study shows UBR5 interacts with the HH pathway to regulate skeletal homeostasis and identifies potential targets for biomedical applications.