Sham Tlili

The paper develops a pipeline for deep imaging and analysis of multi-layered organoids, revealing gene expression patterns and nuclear morphology in gastruloids.

The paper shows that tissue mechanics, specifically Marangoni-like flows, drive symmetry breaking in mouse embryonic organoids, establishing a primary axis through differential surface tension.

The paper develops a biophysical model to explain how cells align over long distances through interfacial energy constraints, demonstrating its applicability to cell matching in the Drosophila heart.

The paper introduces a two-stage framework for detecting cell divisions in 2D and 3D time-lapse images using segmentation and regression models, achieving high accuracy with efficient architectures.

This study shows how cell-state transitions and collective movement create an endoderm-like region in mouse gastruloids without requiring epithelial-to-mesenchymal transition.

The paper investigates the mechanics of Drosophila ventral nerve cord condensation, revealing oscillatory contractions and coordinated mechanical interactions between neurons and glia.

The paper identifies Pcdh18a-positive tip cells that guide notochord formation in zebrafish through migration and signaling.

The paper shows that mutations in different exons of Distal-less (Dll) cause distinct eyespot phenotypes, which are accurately modeled by reaction-diffusion mechanisms.