Yonglong Wei

This paper develops a novel CAR-M targeting GPC3 with IFN-gamma and SIRPECD to enhance anti-tumor activity in hepatocellular carcinoma.

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

This study shows that IGFBP2-expressing midlobular hepatocytes contribute to liver homeostasis and regeneration after injury or fasting.

The paper introduces a deep-learning method called TPS to quantify zonal gene expression patterns in tissues like the liver, showing it can detect differences between strains, ages, and disease states.