Emily D. Egan

This study uses high-throughput biochemical assays to analyze SHP2 variants, revealing that dysregulated autoinhibition drives disease and that allosteric inhibitors stabilize a partially active conformation.

This study identifies somatic Ras-MAPK pathway variants in hippocampal tissue from patients with drug-resistant epilepsy, showing their association with clonal competition and worse surgical outcomes.

This paper designs soluble multivalent Notch agonists to activate Notch signaling in vitro, enabling T cell differentiation and immunotherapy development.

This study tracks Notch and Delta interactions in real-time, showing 1:1 stoichiometry at synapses and NICD nuclear entry after 45 minutes, inhibited by signaling blockers.

This study maps the spatiotemporal dynamics of Notch2 signaling from membrane to nucleus after ligand activation, identifying key molecular events in signal transmission.

The paper investigates the differential requirements for MAML1 in Notch-dependent transcription at HES4 and DTX1, showing distinct functional roles of MAML1 regions and interactions with p300.