Author

Lena Tveriakhina

Harvard UniversityORCID 0000-0001-8659-8207Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Jon Christopher AsteriD· 3 shared Stephen C. BlacklowiD· 3 shared Alexandre P. J. MartiniD· 2 shared Emily D. EganiD· 2 shared Gustavo ScanavachiiD· 2 shared Julia M. RogersiD· 2 shared Tomas L. KirchhauseniD· 2 shared Alina Airich· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

Jon Christopher AsterORCID

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3 papers

Recent·Most cited

BiochemistryStructurePeer-reviewedAug 8, 2024

Structural Requirements for Activity of Mind bomb1 in Notch Signaling

Ruili Cao, Oren Gozlan, Alina Airich…·Stephen C. Blacklow

This study identifies the structural requirements of MIB1 for ubiquitin transfer in Notch signaling, showing that RING3 is essential for catalytic activity and dimerization.

7 citations

experimental assayprotein folding & dynamics

𝕏 PostBluesky

Cell BiologyDevelopmental CellPeer-reviewedApr 3, 2024

Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry

Lena Tveriakhina, Gustavo Scanavachi, Emily D. Egan…·Stephen C. Blacklow

This study tracks Notch and Delta interactions in real-time, showing 1:1 stoichiometry at synapses and NICD nuclear entry after 45 minutes, inhibited by signaling blockers.

14 citations

mousefluorescence / live-cell microscopy

𝕏 PostBluesky

Molecular BiologybioRxivPreprintDec 21, 2022

A Spatiotemporal Notch Interaction Map from Membrane to Nucleus

Alexandre P. J. Martin, Gary Andrew Bradshaw, Robyn J. Eisert…·Stephen C. Blacklow

This study maps the spatiotemporal dynamics of Notch2 signaling from membrane to nucleus after ligand activation, identifying key molecular events in signal transmission.

DOI 10.1101/2022.12.21.521435

humanproteomics

𝕏 PostBluesky