Katarzyna M. Kedziora

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

This study shows oxidative DNA damage destabilizes centromeres, leading to chromosome instability and mitotic defects in pre-tumorigenic cells.

This study maps morphine-induced brain activity in male and female mice over time, revealing sex-specific and time-dependent patterns of c-Fos expression.

The paper identifies two distinct p21-driven pathways to whole-genome duplication in breast cancer cells, both converging on a CDK4/6-dependent polyploid G0 state, and shows that CDK4/6 inhibitors can block WGD and enhance therapy efficacy.

This study identifies cited4a as a regulator that suppresses cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration.

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

This study shows that zinc availability in the tumor microenvironment affects anti-PD1 therapy response in CDKN2A-low tumors through macrophage phagocytosis.

The paper develops two fluorescent reporter systems and imaging platforms to analyze cell cycle phases in living primary human intestinal stem cells.

This study shows AGS3 inhibits LGN to regulate spindle orientation, affecting cell division angles and fate decisions in mammalian epidermis.

This study uses CRISPR/Cas9 and microraft arrays to track OCT4, SOX2, and NANOG dynamics in human stem cells during differentiation, revealing spatiotemporal patterns in germ layer formation.

The paper quantifies MCM loading dynamics in euchromatin and heterochromatin during G1 phase, revealing differential rates and consequences for genome stability.

The paper quantifies cell cycle phase durations in human cells and finds they are memoryless and uncoupled, with a mathematical model explaining their independence and potential coupling under dysfunction.

The paper investigates Cdt1 variants associated with Meier-Gorlin syndrome and a Drosophila allele to uncover their effects on MCM loading, Cyclin/CDK interactions, and genome replication.

The paper shows that OCT4 inheritance predetermines fate choice in human embryonic stem cells, with higher OCT4 ratios in daughters leading to sustained pluripotency and reduced differentiation potential.

The Cell Cycle Browser allows users to visualize, simulate, and perturb cell cycle progression using real-time reporter data from human cells.